Vol. CXIV · No. 1Thursday, June 4, 2026

Reference · Virology

Ebola Species Explorer

Five distinct species of Ebolavirus have been identified. Each has different lethality, geographic range, and outbreak history. Compare them side by side.

Case-Fatality Rate · side-by-side

% of confirmed cases that die

Zaire ebolavirus is the most lethal, killing up to 90% of those infected. Reston has never caused disease in humans.

Zaire ebolavirus (EBOV)

Zaire ebolavirus

Discovered 1976 (Yambuku, DRC)

CFR

60–90%

🦇 Natural host

Fruit bats (Pteropodidae)

🌍 Geography

Central and West Africa

DRC · Guinea · Liberia · Sierra Leone · Gabon · Republic of Congo

Transmission

Direct contact with blood and bodily fluids of infected people or animals. Bushmeat handling, unsafe burials, and nosocomial spread in healthcare facilities are major amplifiers.

Clinical course

Sudden onset of fever, intense weakness, muscle pain, headache, sore throat, followed by vomiting, diarrhoea, rash, impaired kidney/liver function, and in some cases internal and external bleeding.

Notable outbreaks

  • 1976

    Yambuku, DRC

    First identified outbreak — 318 cases, 280 deaths (88% CFR). Transmitted via reused needles at a mission hospital.

  • 2014–16

    West Africa

    Largest Ebola outbreak in history — 28,616 cases, 11,310 deaths across Guinea, Liberia, and Sierra Leone.

  • 2018–20

    Eastern DRC

    Second-largest outbreak — 3,481 cases, 2,299 deaths in North Kivu and Ituri provinces during armed conflict.

Sudan ebolavirus (SUDV)

Sudan ebolavirus

Discovered 1976 (Nzara, South Sudan)

CFR

40–60%

🦇 Natural host

Unknown (bats suspected)

🌍 Geography

East Africa

Sudan · South Sudan · Uganda

Transmission

Direct contact with bodily fluids. Initial outbreaks traced to cotton factory workers with bat exposure. No approved vaccine — rVSV-ZEBOV targets Zaire species only.

Clinical course

Similar to Zaire but with slightly lower fatality. Fever, headache, joint/muscle pain, diarrhoea, vomiting. Haemorrhagic manifestations occur in severe cases.

Notable outbreaks

  • 1976

    Nzara, South Sudan

    284 cases, 151 deaths. Concurrent with but independent of the Yambuku outbreak — initially mistaken for the same virus.

  • 2000–01

    Gulu, Uganda

    425 cases, 224 deaths — the largest Sudan ebolavirus outbreak to date.

  • 2022

    Central Uganda

    164 cases, 77 deaths. No vaccine or therapeutic approved for Sudan species, complicating the response.

Bundibugyo ebolavirus (BDBV)

Bundibugyo ebolavirus

Discovered 2007 (Bundibugyo, Uganda)

CFR

25–35%

🦇 Natural host

Unknown (bats suspected)

🌍 Geography

Central Africa

Uganda · DRC

Transmission

Direct contact with bodily fluids. Less well studied than Zaire and Sudan species due to fewer outbreaks.

Clinical course

Similar to other Ebola species but with lower fatality rate. Fever, haemorrhage, multi-organ failure in severe cases.

Notable outbreaks

  • 2007

    Bundibugyo, Uganda

    149 cases, 37 deaths (25% CFR). Initially misidentified; genome sequencing confirmed a new species.

  • 2012

    Isiro, DRC

    36 cases, 13 deaths. Linked to bushmeat consumption.

Taï Forest ebolavirus (TAFV)

Taï Forest ebolavirus

Discovered 1994 (Taï National Park, Côte d'Ivoire)

CFR

0% (1 case)

🦇 Natural host

Unknown (chimpanzees as intermediate host)

🌍 Geography

West Africa

Côte d'Ivoire

Transmission

Single known human case acquired through necropsy of a dead chimpanzee. The species is known to cause fatal infections in chimpanzees.

Clinical course

The single human case presented with dengue-like illness — fever, headache, myalgia, diarrhoea. Patient survived after evacuation to Switzerland.

Notable outbreaks

  • 1994

    Taï National Park, Côte d'Ivoire

    A Swiss primatologist was infected while performing a necropsy on a dead chimpanzee. Only known human case — survived.

Reston ebolavirus (RESTV)

Reston ebolavirus

Discovered 1989 (Reston, Virginia, USA)

CFR

0% in humans

🦇 Natural host

Pigs, non-human primates (bats suspected reservoir)

🌍 Geography

Philippines, China (animal cases); USA (imported primates)

Philippines · China · United States

Transmission

Identified in cynomolgus monkeys imported from the Philippines to a research facility in Virginia. Causes severe disease in non-human primates but appears asymptomatic in humans. Workers developed antibodies without illness.

Clinical course

No clinical disease documented in humans. Seroconversion (antibody development) has been found in animal handlers and pig farmers with no symptoms.

Notable outbreaks

  • 1989

    Reston, Virginia, USA

    Discovered in imported Philippine monkeys at a quarantine facility. Several workers seroconverted but none became ill. Inspired the book 'The Hot Zone'.

  • 2008

    Philippines

    Found in domestic pigs — first time Ebola was detected in swine. Six pig farm workers had antibodies but no illness.

Want to see live cases? The main tracker shows all confirmed and suspected outbreaks worldwide. For the full history see /history.

Sources: WHO Ebola Fact Sheet · CDC Ebola Virus Disease · ICTV Filoviridae Taxonomy · Lancet Infectious Diseases.

— End of dispatch —